An Overview Of Mesothelioma Cancers
What are Mesothelioma Cancers?
Mesothelioma cancers are the cancers that spread in the mesothelium tissues. Mesothelium in general is the name of tissue that forms lining of different body organs such as heart, lungs, abdomen and...
Asbestos Home Testing- Prevention Is Better Than Cure
Asbestos home testing is a process of testing the presence of asbestos in homes in general and building materials in particular. Asbestos is a mineral fiber resistant to heat, chemicals, and electricity. Building and insulation...
Mesothelioma: New treatments for Mesothelioma cancer
There are more treatment possibilities for Mesothelioma cancer than surgery, chemotherapy and radiation therapy: the clinical trials. They offer no only benefits, but also risks that cancer patients should know before taking part in one of these...
Screening For Mesothelioma
Doctor appointments are critical to make sure you’re staying in proper health. However, exposure to asbestos presents an added urgency for routine appointments. Because asbestos related diseases take decades to form, early detection is critical for...
Treatments And Clinical Trials For Mesothelioma
For years, chemotherapy has been used as treatment for mesothelioma to shrink tumors. More recently, doctors have used surgery in combination with chemotherapy with more success.
In addition, newer chemotherapy drugs in combination with surgery...
Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author: Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.